Small molecule inhibitors of the HIV-1 virulence factor, Nef
نویسندگان
چکیده
منابع مشابه
The Identification of a Small Molecule Compound That Reduces HIV-1 Nef-Mediated Viral Infectivity Enhancement
Nef is a multifunctional HIV-1 protein that accelerates progression to AIDS, and enhances the infectivity of progeny viruses through a mechanism that is not yet understood. Here, we show that the small molecule compound 2c reduces Nef-mediated viral infectivity enhancement. When added to viral producer cells, 2c did not affect the efficiency of viral production itself. However, the infectivity ...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Technologies
سال: 2013
ISSN: 1740-6749
DOI: 10.1016/j.ddtec.2013.07.002